Arsenal conquerors, Olympiacos face another tough English test as they welcome Wolves to the Karaiskakis Stadium in the opening leg of their Last 16 tie.
Liverpool continue to move closer towards a maiden Premier League title following a dramatic round of action affecting both ends of table.
Wolverhampton Wanderers continue their bid for a top four finish as they welcome Brighton & Hove Albion to Molineux.
Premier League leaders, Liverpool saw their 44 league match unbeaten run ended on a dramatic weekend affecting the relegation battle.
Tottenham Hotspur welcome Wolverhampton Wanderers to the Tottenham Hotspur Stadium in a blockbuster clash in the top five race.
Aston Villa meet twice reigning champions, Manchester City in the 2019-20 Carabao Cup Final at Wembley Stadium.
Norwich City welcome Leicester City to Carrow Road in Friday Night Football, as both teams look for a vital win at opposite ends of the table.
Wolverhampton Wanderers head to the RCDE Stadium as they take on Espanyol in the second leg of their Round of 32 tie.
Liverpool continue to hurtle towards a first Premier League title on a weekend in which the top four and relegation battles continue to throw up surprises.
Wolverhampton Wanderers look to continue their bid for a top five finish as they welcome relegation battling Norwich to Molineux on Super Sunday.
Third meets second as Leicester City welcome Manchester City to the King Power Stadium in Saturday Night Football.
Liverpool continue to move towards a first Premier League title after a stormy round of fixtures stretched across a fortnight, as teams enjoyed a winter break despite Storms Ciara and Dennis battering England.
Wolves welcome Espanyol to Molineux in the first leg of their Europa League Round of 32 encounter.
Chelsea welcome Manchester United to Stamford Bridge in a crucial Monday Night Football clash, as both teams look to battle for a top five finish.
Wolverhampton Wanderers host Leicester City at Molineux as both teams look to boost their qualifying hopes of claiming European football next season.