Manchester City welcome local rivals, Manchester United to the Etihad Stadium for the first Manchester derby of the season.
After suffering their first defeat under Jose Mourinho in midweek, Tottenham Hotspur look to hit back as they welcome a shaky Burnley to the Tottenham Hotspur Stadium.
Liverpool continue to march towards the title in a midweek which saw history made, as Amazon Prime aired their first ever round of Premier League matches.
Marco Silva has been sacked by Everton after a poor run of form saw the club slip into the Premier League relegation zone.
Jose Mourinho returns to one of his former clubs as Manchester United meet Tottenham Hotspur in a blockbuster clash at Old Trafford.
West Ham United look to make it consecutive wins in five days as they visit Wolves at Molineux.
Defending champions, Manchester City will begin their FA Cup title defence at home to Port Vale in the Third Round.
Liverpool continue to dominate the Premier League after a lively weekend of surprise results and a relegation six pointer.
Tottenham are looking to make it three wins from three under Jose Mourinho as they welcome Bournemouth to the Tottenham Hotspur Stadium.
Chelsea look to reignite their title challenge as they meet free-falling West Ham in a mouth-watering London derby.