Having taken a dominant midweek European win at Shakhtar Donetsk, Manchester City look to reignite their domestic title hopes as they face Watford at the Etihad Stadium.
Everton take on Sheffield United at Goodison Park as both teams look to bounce back from tough defeats last weekend.
Having stunned the reigning champions – Manchester City last time out, Norwich will be keen to cause another shock as they visit Burnley at Turf Moor.
After suffering their first defeat of the season last time out, Leicester City look to hit back as they take on Tottenham Hotspur at the King Power Stadium.
Southampton take on South Coast rivals, Bournemouth at St Marys’ Stadium in Friday Night Football.
Having stormed through qualifying, Rangers open their second consecutive appearance in the Group Stage with a home clash against Feyenoord at Ibrox.
Celtic kick start their fourth proper Europa League campaign in the last seasons with a trip to Rennes.
Having stormed through qualifying with six wins, Wolves start their proper Europa League adventure at Molineux as they take on Braga.
Manchester United start their Europa League campaign at home to Astana as the Red Devils look to replicate their title winning 2016-17 season.
Having suffered defeat in last season’s final, Arsenal will be hoping it is a case of third season lucky as they start their new Europa League campaign away to Eintracht Frankfurt, who reached the last four last season.