Celtic can take a huge step towards the Europa League knockouts with victory over Lazio at the Stadio Olimpico.
Rangers welcome Porto to Ibrox for a huge Europa League showdown as both teams are locked on four points in Group G.
Wolverhampton Wanderers look to take a huge step towards qualifying for the Europa League knockouts as they meet Slovan Bratislava at Molineux.
Having spent the past fortnight on the road, Manchester United return to Old Trafford as they take on Partizan Belgrade in a crucial Europa League clash.
In a rare Wednesday dose of Europa League action, Arsenal visit Vitoria Guimaraes at Stadio D. Afonso Henriques.
Rangers face a tough test of their Europa League credentials as they visit Porto in Group G at the Estadio do Dragao.
Celtic face a tough test as they welcome Group E favourites, Lazio to Celtic Park for a crucial Europa League clash.
Partizan Belgrade welcome Manchester United to the Partizan Stadium as both teams do battle in a crunch top of Group L clash in the Europa League.
Wolves continue their European adventure as they visit Slovan Bratislava at Tehelne Pole in Group K.
Arsenal can take a huge step forward in escaping Group F if they can see off Vitoria Guimaraes at the Emirates Stadium.