Having snatched a super late 1-1 draw at the Riverside Stadium just over a week ago, Newport will be smelling blood as they aim to make it four home FA Cup games unbeaten against higher opposition.
Middlesbrough meanwhile know that victory will bag them a home tie against Manchester City in the fifth round.
Newport County could start Joe Day in goal, after he missed the draw due to his wife being due to give birth.
Several first team regulars who were rested at weekend against Grimsby are all set to start with Padraig Amond amongst those set for a recall.
Middlesbrough have a full squad available with only midfielder, Lewis Wing set to be sidelined as he struggles with a groin injury.
Middlesbrough need to be wary here of Newport who have lost just two home games all season in all competitions.
Saturday’s comeback win from 2-1 down at West Brom however will give them the confidence they need to go and kill this game off within normal time.
Prediction: Newport County 0-2 Middlesbrough
Result: Newport County 2-0 Middlesbrough