Whoever wins here will visit Accrington Stanley in the next round live on BT Sport, meaning that additional TV money as well as progress is at stake here.
Southampton will be without the suspended trio of Charlie Austin, Pierre-Emile Hojbjerg and Yan Valery.
Ryan Bertrand (back), Danny Ings and Michael Obafemi (thigh) are ruled out whilst Mario Lemina is a fitness doubt.
Defender, Maya Yoshida is absent as he continues to participate in Asian Cup with Japan.
Derby have striker, Harry Wilson available after the Liverpool loanee sat out their last two games with a hip issue.
Curtis Davies (Achilles), Craig Forsyth and Marcus Olsson (knee) are all long-term absentees for the Rams.
Southampton are showing real progress under Ralph Hasenhuttl and if can tighten up at back, they should win this against a tricky Derby side.
Prediction: Southampton 2-1 Derby County