Whilst the hosts will be looking to cause a massive cupset, for Tottenham this is a chance to get a cup double bid underway as Mauricio Pochettino continues to be linked with Manchester United.
Tranmere Rovers have midfielder, Olli Banks available after recovering from a hernia injury.
On loan signing – Luke McCullough has been cleared to play for the White Army after receiving permission from parent club, Doncaster Rovers.
Tottenham right-back, Serge Aurier faces a late fitness test after recovering from a recent groin injury.
Fernando Llorente meanwhile is set to start with Harry Kane rested ahead of next week’s Carabao Cup clash with Chelsea, where Erik Lamela could feature after returning to training this week from illness but won’t be risked here.
Mousa Dembele (ankle), Jan Vertonghen (thigh) and Eric Dier (appendix) won’t be risked here or against Chelsea but have all resumed training.
Victor Wanyama (knee) and Vincent Janssen (foot) are both ruled out indefinitely.
Tranmere will give this a real go but Spurs are a side in fierce form with two domestic defeat in their last 13 outings.
Add in the depth of their squad then I can see another comfortable away win to follow up their midweek thumping of Cardiff City.
Prediction: Tranmere Rovers 0-3 Tottenham Hotspur
Result: Tranmere Rovers 0-7 Tottenham Hotspur