Both teams are fighting at opposite ends of table and know victory will be crucial in their respective battles.
Chelsea are set to name their usual starting eleven after making mass changes in midweek, with Eden Hazard expected to start after recovering from his ankle injury.
Oliver Giroud is however set to move onto sidelines with an ankle injury picked up against PAOK Salonika.
Fulham have no new injury issues but Andre-Frank Zambo Anguissa (thigh) and Kevin McDonald (hamstring) remain absent.
Chelsea saw their unbeaten league start to this season end last time out after falling to a 3-1 defeat against London rivals, Tottenham Hotspur.
They however hit back in midweek Europa League action by beating PAOK Salonika 4-0 to make it 11 home games unbeaten in all competitions this season.
League wise though, they have drawn three of their last four home games with the draws all coming against fellow top ten sides.
Fulham meanwhile ended a six match losing streak with a home win over Southampton last weekend.
Away form however has been an issue with just one point from seven away trips, and haven’t scored on three of their last four travels.
Although Claudio Ranieri will have Fulham playing a strong attacking game, their defence is still a concern and therefore I can see Chelsea winning this.
Prediction: Chelsea 2-0 Fulham
Jake predicts: Chelsea 3-2 Fulham
Result: Chelsea 2-0 Fulham