Chelsea then meet Everton before Manchester City could potentially return top with victory in the Manchester derby, depending on earlier results.
Arsenal are also in action at home to Wolverhampton Wanderers as they aim to make it 16 unbeaten.
Liverpool need to hit back here from a shock midweek defeat at Red Star Belgrade and could go top with victory.
Fulham meanwhile have been atrocious at the back all season and despite their impressive attack, they lack that clinical edge when get chances which they must take against Liverpool.
Otherwise, I can see a heavy loss coming here if the Reds are at their attacking best.
Prediction: Liverpool 4-0 Fulham
Jake predicts: Liverpool 3-0 Fulham
Result: Liverpool 2-0 Fulham
This could well be the tie of the day as both teams enter this in fine goal scoring form.
Chelsea are still unbeaten in all competitions but have conceded in their last four home league games, whilst Everton have scored in last five but are yet to keep a clean sheet on the road.
Those stats therefore makes this exciting because Chelsea are difficult to beat at home despite leaking in goals but Everton are currently on a goal scoring run with Gylfi Sigurdsson and Richarlison scoring six of their last eleven goals between them.
Prediction wise, this is tough given the form of both sides but Everton haven’t won at Stamford Bridge in the league since November 1994.
Prediction: Chelsea 2-1 Everton
Jake predicts: Chelsea 2-2 Everton
Result: Chelsea 0-0 Everton
Arsenal are still unbeaten in 15 but Wolves will pose a stern test despite losing their last three on the bounce.
I can see Wolves trying to utilise crosses and set pieces here because they are going to really struggle to score in open play against the Gunners, who are dangerous both in and outside of the box.
Throw in the fact that Arsenal have only conceded three goals against Wolves in the Premier League era, then there will be only one result.
Prediction: Arsenal 3-0 Wolverhampton Wanderers
Jake predicts: Arsenal 2-1 Wolverhampton Wanderers
Result: Arsenal 1-1 Wolverhampton Wanderers
Manchester City have gone unbeaten in the opening 11 rounds but Manchester United are currently in revived form.
That rediscovered sprit is definitely going to be tested here because in the past week, City have managed to net 12 goals at home and were on a whole new ferocious level against Southampton last Sunday.
As a result, United are probably meeting City at a wrong time given that their two wins last week both were from behind, and I am struggling to see how they can mount something similar here given the gulf in overall quality.
If there is one weakness that the Citizens have, its that when several of them get into box they aren’t clinical enough to find space and lash the ball in as we saw against Southampton in 36th minute, when they played EIGHT passes in centre of box and not one shot was attempted.
Overall, I am struggling to see how United can find a way past a City side who have topped all the attacking stats so far this season and is in scary form.
Prediction: Manchester City 3-0 Manchester United
Jake predicts: Manchester City 2-0 Manchester United
Result: Manchester City 3-1 Manchester United