A win for either side will send them top but a draw will hand those around them a chance to leapfrog them both depending on later results.
Middlesbrough will be without Ryan Shotton as the full-back faces a few weeks on sidelines with a knee injury.
Paddy McNair will again deputise for the ex Birmingham City player.
Derby are without Craig Bryson (calf) and George Evans (knee) so may remain unchanged from Wednesday’s win over West Bromwich Albion.
Middlesbrough have been inconsistent this month, picking up two wins either side of a home loss to Nottingham Forest before drawing last time out to Rotherham.
At home, Boro have only conceded twice with both goals coming at the hands of Forest earlier this month but have kept a clean sheet in six of their seven home games so far overall.
Derby meanwhile arrive here in high spirits after dispatching two promotion rivals in Sheffield United and West Brom this past week, scoring six and conceding twice.
The Rams however haven’t kept a clean sheet in last six games since a goalless draw with Blackburn in mid September.
This should be a tight game here because Boro don’t tend to do comfortable thrashings under Pulis but Derby are riding high on confidence after the past week.
Both teams will score but I feel that Derby will edge this because the momentum is with them at minute and their attack is fierce.
Prediction: Middlesbrough 1-2 Derby County
Result: Middlesbrough 1-1 Derby County