With both Manchester clubs, Bristol City and Leicester amongst those through, attention now turns to the Capital for two thrillers.
Under pressure Slaven Bilic takes his West Ham side to Wembley to face an in form Tottenham Hotspur.
Across in West London, Everton visit Chelsea without Ronald Koeman after sacking him on Monday.
Tottenham Hotspur vs West Ham
Tottenham enter this game looking to maintain momentum after recording their first home win at Wembley on Sunday.
West Ham however need a win to ease the pressure on Bilic after Friday’s 3-0 home annihilation by Brighton.
Both teams are set to make changes with Mousa Dembele and Andy Carroll amongst those expected to come in for each side.
There have been eight League Cup meetings between these clubs with both teams taking three wins each.
The other two clashes ended in draws but happened under the old two legged format, with Tottenham winning the ties on aggregate with second leg wins.
Coming back to October 2017 now, this will be a tough fixture for the Hammers and I can only see one winner.
Even with changes, Spurs have quality all over the pitch with the likes of Harry Winks and Fernando Llorente expected to feature. That is what will get them a comfortable win here.
Prediction: Tottenham Hotspur 2-0 West Ham
Result: Tottenham Hotspur 2-3 West Ham
Chelsea vs Everton
Chelsea will be happy to enter this under the kosh with attention firmly on Everton after sacking Koeman.
Both teams are likely to feature strong teams here with the Toffees particularly needing to send out a huge message.
Chelsea goalkeeper, Thibaut Courtois however reckons that Everton’s league form won’t affect this match.
Speaking ahead of tomorrow night to Chelseafc.com, the Belgian said; ‘Everton have been struggling at the moment. I don’t think they are playing badly but they have conceded some sloppy goals, and other teams have had more luck, but the Premier League is hard. This is another competition, though, and they will be ready to win it.’
If look at the head to head record in this competition, Chelsea have won six of their eight meetings and drew the other two.
Both draws came under the old format of two legged ties per round, in 1985-86 and 1992-93 competitions.
These teams contested one of the 2007-08 semi finals with the Blues winning both legs with a 3-1 aggregate result.
A decade on from that semi final, both teams have had 12 managerial changes between them with 10 coming at Stamford Bridge.
Everton have had only one interim manager in that time unlike Chelsea’s two and he won his only game in charge (Norwich in May 2016).
He is now back in temporary charge but I can’t see him conjuring another win up here, given the Toffees’ defensive sloppiness.
Prediction: Chelsea 3-0 Everton
Result: Chelsea 2-1 Everton