Europe might rule this midweek but there is a rearranged Premier League game to be played between the Saints and Gunners.
Southampton welcome Arsenal to St Marys as both sides look to finish the season on strong notes.
Southampton have no new injury concerns.
Charlie Austin and Matt Targett could make returns from injury, before the end of this season.
Virgil van Dijk and Alex McCarthy are both ruled out till next season.
Arsenal are unlikely to risk Laurent Koscielny and Granit Xhaka, who both have calf injuries.
Santi Cazorla is definitely out with an ankle injury, picked up in early March
Forward, Lucas Perez is still missing with a thigh muscle strain picked up during the game against West Bromwich Albion.
The Saints have a chance to win three home games in this league fixture on the bounce.
That is a tough ask though, Southampton have only beaten Arsenal six times in the top flight with 19 defeats.
The Gunners have however not won here since 2003, excluding cup competitions.
Stuck in ruts
Both sides haven’t had the best time of it this season, especially coming into this clash.
Southampton have struggled at home for goals, having only scored 11 in 12 home matches.
Claude Puel will be hoping that Manolo Gabbiadini can end his poor run and get his first goal since the 4-3 win at Watford.
They are also without a win in four and anything less here will result in their worst run of form all season.
Arsene Wenger on the other hand shouldn’t get too giddy at his side’s chances.
Arsenal have lost five of their last six on the road with just one clean sheet in that period.
Now that the final Champions League spot has opened back up again, they must take advantage and win all of their remaining games. There is no better time to reverse their away form by winning here.
Given that both teams played on Sunday, expect a tight battle with rotated sides.
The fact that Southampton have drawn plenty of blanks this season home and away, makes this a tough ask.
Arsenal might be woeful away from home but have improved since going to a 3-4-3 formation against Middlesbrough.
That will help them here against an organised side, who are surely low on confidence.
Prediction: Southampton 0-2 Arsenal
Result: Southampton 0-2 Arsenal